What Are The Benefits Of A NADH IV?

If you have been exploring IV therapy, you may have come across NADH. What are these treatments, and what conditions can they address? Are there any side effects? Read on to learn more about NAD therapy and decide if it is the right treatment for you.

What is NADH?

NAD is an acronym for Nicotinamide Adenine Dinucleotide, a cofactor and coenzyme of niacin (Vitamin B3) that occurs naturally in the body. NAD plays a vital role in the metabolic process, converting the energy from food into cellular energy. As we age, NAD levels naturally fall, sometimes not generating enough NAD for your body to function efficiently.

NAD therapy involves replenishing the body with NAD to fuel other key biological processes, including:

  • Fortifying cell defense systems
  • Repairing DNA damage
  • Setting circadian rhythm

NAD therapy can come in a few different forms, characterized by what stage of chemical reaction at which the NAD supplement is supplied. NAD, the initial form, must undergo chemical reactions during the metabolic process, including oxidation and reduction. The oxidized form of NAD is NAD+; this allows NAD molecules to accept electrons from other molecules.

NAD+ is the precursor to most NAD chemical reactions, which means it can immediately be used by the body to power various processes. In contrast, NAD supplied to the body would first have to be oxidized within the body before being used for those processes.

NADH is NAD+ with the addition of two hydrogen atoms, which provide extra electrons. This process is known as reduction. NAD+ and NADH pass electrons back and forth to create a catalytic chain reaction. This reaction is vital to various body processes.

What are the benefits of a NADH IV?

Replenishing the body’s NAD supply offers several potential benefits.


NAD+ activates other enzymes that have been linked to healthy aging. One of these is Poly (ADP-Ribose) polymerases (PARPS), which aids in the repair of damaged DNA. Increased PARP activity has been associated with less damage in DNA and a longer lifespan.

Another enzyme activated by NAD+ is sirtuins, which are believed to have several benefits for healthy aging, including:

  • Boosted stress resistance
  • Calorie restriction, which helps extend lifespan
  • DNA repair
  • Inflammation reduction

NAD+ has also been shown to promote healthy muscle aging through improved muscle endurance, function, and strength.


As explained already, NAD is vital to the energy processes of the body. NADH therapy has been explored by researchers as a treatment for those with chronic fatigue syndrome. Although studies are still ongoing, researchers have some theories as to why NADH is beneficial.

  • NADH may help the brain create neurotransmitters related to mood and cognitive function.
  • NADH aids in converting food into adenosine triphosphate (ATP), a form of energy. Chronic fatigue syndrome has been linked to low ATP levels.
  • NADH is believed to restore mitochondrial function, helping to reduce fatigue.
  • NADH can stimulate brain function, which is believed to help relieve cognitive dysfunction associated with chronic fatigue syndrome.


Because NAD is vital to metabolic processes, supplementing the body with NAD has been shown to increase metabolism. This increased metabolism has been linked to weight loss, though more research is needed before NAD is approved as a weight loss treatment. Counteracting the natural loss of NAD through aging with NAD therapy helps ensure your metabolic function does not suffer due to NAD loss.

Cognitive Function

NAD+ has been shown to play an essential role in helping protect brain cells from aging. NAD+ helps manage the production of a protein called PGC-1-alpha, which protects cells against impaired mitochondrial function and oxidative stress. Both mitochondrial function and oxidative stress have been associated with age-related brain disorders like Alzheimer’s disease and Parkinson’s disease.

NAD+ also helps fight inflammation associated with decline in cognitive function, which has also been tied to conditions like Alzheimer’s and Parkinson’s. By protecting brain cells from damage, the brain’s ability to adapt to changing environments, known as plasticity, is preserved. Neuronal stress resistance, which is vital to cognitive function, is also maintained, preventing neurons from misfiring messages.

Addiction Recovery

NAD therapy can help those recovering from substance abuse disorder in a number of ways.

  • Aids in flushing drugs from the body
  • May reduce withdrawal effects, helping to prevent relapse motivated by inability to deal with uncomfortable and painful symptoms associated with detox
  • Helps the body naturally generate energy, helping to combat detox-related fatigue. This also helps patients avoid crashes or jitters associated with attempts to boost energy using caffeine, sugar, or other substances.
  • May curb cravings for substances and lessen pain associated with withdrawal, also helping to prevent relapse.

Administration of NAD to addiction recovery patients can help acute withdrawal symptoms from alcohol or opiates, such as:

  • Anxiety
  • Cravings
  • Depression
  • Stress

NAD therapy for addiction usually involves multiple sessions over a period of time. The duration of NAD-assisted recovery can vary depending on the substance involved and the severity of the addiction, among other factors.

Are there any side effects?

There are few side effects associated with NAD therapy, which has largely been studied over periods of a short duration. Because the study of NAD therapy is still ongoing, the long-term side effects are fairly unknown.

Some mild to moderate side effects of NAD therapy patients may experience include:

  • Abdominal pain
  • Diarrhea
  • Fatigue
  • Headaches
  • Indigestion
  • Nausea

There are also some side effects associated with the infusion administration method itself. These include:

  • Air embolism
  • Vein damage
  • Infection at site of injection

When receiving treatment from a licensed and trained healthcare professional, the risk of these side effects is significantly mitigated. Procedural and hygiene protocols are designed to prevent these side effects from occurring.

What should I expect from a NADH IV appointment?

Before beginning NAD treatments, your provider should conduct a health screening to determine whether or not NAD therapy is the right choice for you. In addition to ensuring your provider is a licensed and trained healthcare professional, you should also inquire about the lab where their therapies are sourced from. Labs should be certified and operate according to US Food and Drug Administration (FDA) operating standards.

Whether you get treatments at home or at a clinic, your nurse will administer the treatment directly into your bloodstream via a needle, catheter, and sterile saline solution containing NAD and vitamins. This type of infusion typically takes 2 – 3 hours, during which time you can read a book, watch a movie or show, or even work. Your nurse will monitor your progress during your infusion. After treatment, you can resume your daily activities as normal.

Get NAD Therapy Without Leaving Home

For the best NAD IV therapy in your area, skip the clinic and get in home NAD therapy with Drip Hydration. Even if you are healthy, you can benefit from increased energy, better sleep, faster healing, and improved cognitive performance.  Contact us to learn more and to schedule your next treatment!

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