A single metal injection filled with blue liquid.

Vitamin D Injections vs. Supplements

A single metal injection filled with blue liquid.

When getting your daily Vitamin D dose, deciding between taking a Vitamin D supplement or receiving a Vitamin D injection can be difficult. Both methods have advantages and disadvantages, but it is imperative to understand the primary differences before deciding.

In this blog, we will compare Vitamin D injections to Vitamin D supplements and discuss which is more effective in providing the body with the necessary Vitamin D.

Vitamin D injections

Vitamin D injections are a form of vitamin D supplementation involving the injection of the nutrient directly into the body.1 Vitamin D injections can help people with low vitamin D levels. Unlike oral supplements, Vitamin D injections are more effective as they provide a higher and faster nutrient absorption into the body.

Vitamin D injections can immediately increase the vitamin D levels in the bloodstream.

injection and bottle held in a doctor's hand.

Vitamin D is vital for maintaining healthy teeth and strong bones and helps the body absorb calcium. It also helps regulate immune system function and cell growth. Additionally, Vitamin D can help protect against certain cancers, heart disease, and even depression.

Vitamin D injections benefits

Vitamin D injections provide a more effective method of getting the vitamin into your system than oral supplements because they deliver concentrated doses directly into the bloodstream, resulting in faster absorption and more efficient nutrient use.

Vitamin D injections can help to support strong bones, as well as help to regulate calcium and phosphorus levels in the body. They may also reduce the risk of developing osteoporosis, reduce the risk of cancer, and provide other health benefits.

Vitamin D injections side effects

Though Vitamin D injections are generally considered safe, there is always the potential for side effects. Prevalent side effects include a temporary stinging or feeling of warmth at the injection site, nausea, and fatigue.

Allergic reactions to Vitamin D injections can also manifest as rashes, itching, or swelling of the face, throat, or tongue. Speaking with your healthcare provider if you experience any of these symptoms after injection is essential.

Oral Vitamin D supplements

Vitamin D Supplements are an oral form of vitamin D ingested daily or in higher doses, as needed. These supplements are available over the counter in various forms, including tablets, capsules, and liquids. They provide a convenient way to ensure you are getting enough vitamin D.

vitamin d package and pills

How vitamin D supplements work

Vitamin D Supplements are absorbed through the digestive system and then travel to the liver and kidneys before being reformed into an active form that the body can use. This active form, called calcitriol, helps regulate calcium levels in the body and supports bone health. Vitamin D also helps support the immune system, heart health, and other vital functions.

Vitamin D supplements benefits

Vitamin D supplements offer several potential benefits. First and foremost, vitamin D supplements are convenient ways to meet your daily requirements for vitamin D. You can purchase them over-the-counter at most grocery stores, drug stores, and health food stores. Additionally, they may benefit people who need access to or need to take advantage of sunlight exposure.

Vitamin D supplement side effects

Vitamin D, when taken in excess, can lead to a variety of side effects, including:

  • Nausea and vomiting
  • High calcium levels in the blood
  • Bone pain
  • Kidney damage
  • Allergic reactions

Following the recommended vitamin D supplements dosage is vital to avoid potential side effects. Contact your doctor immediately if you observe any of these side effects after taking a vitamin D supplement.

Vitamin D injections and supplements comparison

When it comes to efficacy, vitamin D injections are far more effective than oral supplements. Single-shot injections of vitamin D deliver significantly higher concentrations of vitamin D into the bloodstream than oral supplements, resulting in faster and more efficient overall absorption.

In terms of convenience, oral supplements are far easier to take, as they can be taken daily without needing needles or appointments.

Concerning cost, vitamin D injections can be more expensive due to the need for medical appointments and the higher dosages. On the other hand, oral supplements can be relatively inexpensive depending on the brand and quantity purchased.

Injections are generally safe but may cause discomfort at the injection site, redness, and swelling. Oral supplements, while generally safe, may cause nausea, vomiting, headache, loss of appetite, and constipation.

Which is better: vitamin D injections or supplements?

The answer is centered squarely on the individual’s health needs and preferences. Regarding vitamin D, injections are generally more effective due to higher and faster absorption. However, some people may be more comfortable with the convenience of oral supplements.

When making the decision, you should consider several factors, such as your current health status, dietary intake of vitamin D, and lifestyle habits. Additionally, if you are pregnant, lactating, or have any medical conditions that make you more prone to vitamin D deficiency, you should discuss your options with a healthcare provider.

Overall, vitamin D injections and supplements can be beneficial depending on an individual’s circumstances. To ensure adequate amounts of vitamin D and determine which option is best for you, consult your healthcare provider.

When to choose vitamin D injections

Vitamin D injections can benefit those looking for quick, high doses of the vitamin necessary to reach optimal levels quickly. Vitamin injections are especially beneficial in cases where a person has a condition that affects the body’s ability to absorb vitamin D, such as malabsorption syndrome, pancreatic insufficiency, Crohn’s disease, or celiac disease.

hand in glove and syringe

Vitamin D injections can also help treat vitamin D deficiency caused by dietary deficiencies, such as inadequate intake of dairy products and fortified foods.

When to choose vitamin D supplements

Vitamin D injections are more effective due to their higher and faster overall absorption, but that does not mean supplements are necessarily the wrong choice. Supplements can be an excellent option for those looking for an easy, cost-effective way to get their daily dose of vitamin D.

Supplements offer several benefits over injections, including:

  • Ease of use: Supplements are easy to take and do not require an appointment with a doctor or nurse.
  • Cost: Vitamin D supplements are usually much less expensive than injections.
  • Convenience: Supplements can be taken with you anywhere, making them an ideal choice for busy people.
  • Flexibility: Supplements come in various forms, including pills, gummies, liquids, and powders.

Vitamin D supplements can be a good choice for those who need a daily vitamin D supplement but do not wish to receive an injection. However, if you have difficulty absorbing vitamin D or have a medical condition such as osteoporosis, it is best to speak to your doctor before taking any supplements.

Last words

Vitamin D injections and supplements can effectively provide adequate Vitamin D levels. Injections offer higher and faster absorption rates and may be the best choice for individuals who need to quickly increase their Vitamin D levels, such as those with severe deficiencies. Ultimately, deciding which to use should be based on individual needs and preferences.

Regardless of your preferred method, Vitamin D is essential for many bodily functions, and adequate levels are crucial for maintaining good health. Additionally, discussing proper supplementation with a healthcare professional is always recommended to ensure safety and effectiveness.

Get an In-Home Vitamin D Shot

Vitamin D helps support healthy energy levels, mood, immune function, and more. Replenish low levels of this essential vitamin with in-home shots administered by one of our registered nurses.

Learn more or schedule an appointment today by clicking the button below!

Vitamin D Shots - Frequently Asked Questions

Can you take too much vitamin D?

Yes, it is possible to take too much vitamin D. Vitamin D is a fat-soluble vitamin, which means that it can build up in the body and potentially lead to toxic levels if it is consumed in large amounts. Vitamin D toxicity can cause hypercalcemia, a buildup of calcium in your blood. This condition can cause symptoms such as weakness, nausea, vomiting, frequent urination, kidney problems, and more.

How often do you need vitamin D shots?

Frequency of treatment depends on individual circumstances such as the severity of vitamin D deficiency, medical history, and other factors. However, most people may receive 1 – 3 shots over the course of a year.

Are vitamin D shots better than oral supplements?

Yes. Because vitamin D shots are given intramuscularly, the ingredients bypass your digestive system so that the full dose is available to your body for maximum benefits. Vitamin D shots are rapidly available for your cells to use.

What happens if you don’t treat vitamin D deficiency?

Not treating vitamin D deficiency can cause rickets, a rare but treatable condition that causes fatigue, frequent illnesses, depression, and impacts bone and muscle health. In children, vitamin D deficiency can impact normal growth and development.

Read more: Vitamin D Shots FAQ


[1] Gupta N. - Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency.;