woman with her back turned showing her hair

GHK-Cu Peptide For Hair Loss Treatment: How Does It Work?

GHK Cu hair growth peptide is a newer treatment option for those experiencing hair thinning or loss, working in several different ways to promote hair growth. As a naturally-occurring peptide, GHK-Cu may offer fewer side effects than traditional treatments while supporting stronger, healthier, and fuller hair. Treatments are simple daily applications directly to the scalp, and results are typically seen after several months of consistent use.

GHK-Cu Peptide Therapy

GHK-Cu is a copper peptide used for its potential anti-aging and regenerative properties. Boost collagen, reduce wrinkles, and restore skin elasticity with this powerful peptide.

Hair loss is a widespread concern in the US and beyond. Although it is common, especially as people age, it’s often troubling for those who experience it.1 Ongoing research aims to identify the safest and most effective treatments.

Standard treatment options for hair loss currently include hair follicle transplantation (which is thought to be effective, but invasive, and inaccessible to most people due to the high cost), and prescription medications, which are more convenient but often come with the risk of side effects.2

GHK Cu hair growth peptide is one promising alternative solution for hair loss.3

woman with her back turned showing her hair

This naturally occurring group of peptides and copper may promote hair growth, improve scalp health, strengthen hair, and reduce inflammation and other factors that may contribute to hair loss. It’s also thought to be a safe option for most people, and is widely available where beauty and haircare products are sold.

What Is GHK-Cu Peptide?

GHK-Cu peptide, also referred to as copper peptide or copper tripeptide-1, is a combination of two components: GHK (a group of the amino acids glycine, histidine, and lysine) and the essential element copper (Cu).

GHK-Cu occurs naturally in the body, and is used to stimulate the production of collagen and elastin, improve tissue repair and wound healing, reduce inflammation and oxidative stress, modulate gene expression, and maintain the structure and integrity of your skin and hair, among other healing and regenerative functions. (4, 5)

As you get older, your levels of GHK-Cu naturally decrease. This is thought to be a contributing factor to some of the most common effects of aging, including thinning hair, slower wound healing, and decreased strength and elasticity of your skin.

By supplementing your gradually decreasing supplies of GHK-Cu through skin and hair products containing the peptide, you may therefore be able to slow, reduce, or even reverse some of these effects.6

GHK-Cu Peptide and Hair Growth

GHK Cu peptide for hair is thought to work in a number of different ways to promote stronger, thicker, healthier hair; accelerate growth; reduce thinning and loss; and repair scalp damage.7

While clinical trials on GHK Cu peptide for hair growth are limited, they are promising, and a number of mechanisms have been proposed for how the peptide complex may work.

GHK Cu hair growth peptide may work by:

Increasing blood flow to the scalp

GHK-Cu peptide may help to improve blood circulation to the scalp and hair follicles (the tiny structures through which hair grows).8 Improved blood flow in turn provides hair follicles with the nutrients and oxygen they need in order to allow hair to grow.

Extending the hair growth phase

Hair growth happens in cycles.9 One common contributing factor to hair loss is a shortened cycle, which can happen as a result of hormonal changes or issues with your hair follicles. Copper peptides may help to extend the growth phase, allowing more time for active lengthening (and less time for shedding).

Boosting production of collagen and elastin

The proteins collagen and elastin are essential components of strong, healthy hair. As you get older, your levels of both naturally decrease.10 GHK-Cu is thought to promote the production and synthesis of the collagen and elastin that surrounds hair follicles, enhancing growth and strength.11

Protecting the scalp with anti-inflammatory and antioxidant properties

GHK-Cu may help to improve scalp health and repair damage by reducing inflammation and oxidative stress.12

Increasing hair follicle growth and size

Research has shown that GHK-Cu can encourage the growth of new hair follicles.13 Copper peptides may also increase the size of existing hair follicles, which is thought to enhance volume and thickness.

Side Effects of GHK-CU

GHK Cu  for hair loss is thought to be a safe option for most people, with a low risk of side effects.

When introducing a new product to your skin (including your scalp), it’s always a good idea to start with a patch test.

Apply a small amount of your GHK-Cu serum or other product to an isolated patch of skin where it isn’t likely to be rubbed off quickly (the underside of your arm or elbow is usually a good choice). Leave the product on for 24 hours, and monitor yourself for any adverse reactions or signs of an allergy.

Possible reactions may include itchiness, redness, hives, or a feeling of stinging or burning. If you don’t experience any adverse effects from your patch test, you can likely begin to use the product on your scalp.

If you do experience any signs of allergy or irritation, either during your patch test or after more prolonged use of copper peptides, discontinue use and speak with your practitioner.

There is a potential risk of copper toxicity if the ingredient is used in excess. However, if purchasing a product from a reputable company and using it according to the package directions, this is unlikely.

How to Use GHK-Cu Peptide for Hair Loss

GHK Cu for hair loss is often sold as a hair serum, which can be massaged directly onto your dry or damp scalp, or as a shampoo or conditioner.

Exact directions may vary depending on the product you choose, but generally, a GHK-Cu serum should be applied directly to your dry or damp scalp once daily, massaged evenly and thoroughly, and not rinsed out. Serums are very concentrated, and you typically only need to use a drop or two at a time.

If choosing a shampoo or conditioner, it’s a good idea to take a look at the full list of ingredients to see if GHK-Cu is a primary one. Some products may only contain very small amounts, even if they advertise the ingredient prominently.

GHK-Cu injections are also available in some wellness centers and clinics. Injections are a precise and potent delivery method, but they are also more invasive and costly, and can be irritating for some.

Consistency is key. Most people will notice improvements within about 3 months of daily use of a GHK-Cu serum or other topical product. It’s important to stick with the routine in order to have the best chance of seeing results.

You may also want to combine GHK-Cu with other scalp and hair supporting treatments for additional benefits. GHK-Cu can be used in combination with other products, but it’s usually best to leave at least 10-15 minutes between the application of different hair serums.

Certain products, like retinol and vitamin C, may alter the effectiveness of copper when used simultaneously. They should therefore be applied at different times of the day.

Conclusion

GHK-Cu is a generally safe, non-invasive, and promising alternative treatment for hair loss. While more research is needed, the current body of knowledge suggests that GHK-Cu may work in several different ways to promote hair growth, strength, and volume; prevent thinning; and improve scalp health.

It’s always best to consult with a healthcare professional before introducing GHK-Cu, or any other new hair loss treatments. Remember to start with a patch test in order to determine that your skin doesn’t react to copper peptides, and keep in mind that a consistent routine is key.

GHK-Cu Peptide Therapy

As skin ages, collagen and elastin decrease, leading to wrinkles and reduced firmness. GHK-Cu has the potential to increase the formation of these proteins, offering numerous anti-aging benefits such as enhanced wound healing, antioxidant properties, reduced wrinkles, improved skin tone, and overall skin rejuvenation. Embrace your skin's potential. Order now and experience the transformative power of GHK-Cu.

Peptide Shots - Frequently Asked Questions

What is included in our peptide injections?

There are many different peptide injections that we offer as part of a peptide therapy including Sermorelin and PT-141.

What is SERMORELIN?

Sermorelin is a synthetic form of GHRH (growth hormone-releasing hormone) which controls the hGH (human growth hormone) and it’s recommended to people who have low levels of hGH. 

How do peptides improve your sleep?

Serotonin is a neurotransmitter present in the brain that releases chemicals as messages to your brain and body that it is time to go to sleep. Some peptides can interact with serotonin. Serotonin regulation issues can definitely interfere with a person's ability to have a good night's sleep.

Sermorelin is recognized for their potency as peptides that may potentially enhance sleep.

How do peptides improve immune health?

The immune response can be either blocked or stimulated to produce tolerance using peptides and peptidomimetics as immunomodulating agents.

Read more: Peptide Shots FAQ

References

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[2] Suchonwanit P, Thammarucha S, Leerunyakul K. Minoxidil and its use in hair disorders: a review. Drug Des Devel Ther. 2019 Aug 9;13:2777-2786. doi: 10.2147/DDDT.S214907. Erratum in: Drug Des Devel Ther. 2020 Feb 10;14:575. doi: 10.2147/DDDT.S247601. PMID: 31496654; PMCID: PMC6691938.;

[3] Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC, Cho KH, Kim KH. The effect of tripeptide-copper complex on human hair growth in vitro. Arch Pharm Res. 2007 Jul;30(7):834-9. doi: 10.1007/BF02978833. PMID: 17703734.;

[4] Ma WH, Li M, Ma HF, Li W, Liu L, Yin Y, Zhou XM, Hou G. Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways. Life Sci. 2020 Jan 15;241:117139. doi: 10.1016/j.lfs.2019.117139. Epub 2019 Dec 4. PMID: 31809714.;

[5] Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. PMID: 29986520; PMCID: PMC6073405.;

[6] Dou Y, Lee A, Zhu L, Morton J, Ladiges W. The potential of GHK as an anti-aging peptide. Aging Pathobiol Ther. 2020 Mar 27;2(1):58-61. doi: 10.31491/apt.2020.03.014. PMID: 35083444; PMCID: PMC8789089.;

[7] Lee WJ, Sim HB, Jang YH, Lee SJ, Kim do W, Yim SH. Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth. Ann Dermatol. 2016 Aug;28(4):438-43. doi: 10.5021/ad.2016.28.4.438. Epub 2016 Jul 26. PMID: 27489425; PMCID: PMC4969472.;

[8] Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxid Med Cell Longev. 2012;2012:324832. doi: 10.1155/2012/324832. Epub 2012 May 10. PMID: 22666519; PMCID: PMC3359723.;

[9] Burg D, Yamamoto M, Namekata M, Haklani J, Koike K, Halasz M. Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process. Clin Cosmet Investig Dermatol. 2017 Feb 27;10:71-85. doi: 10.2147/CCID.S123401. PMID: 28280377; PMCID: PMC5338843.;

[10] Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006 Jun;168(6):1861-8. doi: 10.2353/ajpath.2006.051302. PMID: 16723701; PMCID: PMC1606623.;

[11] Siméon A, Wegrowski Y, Bontemps Y, Maquart FX. Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+). J Invest Dermatol. 2000 Dec;115(6):962-8. doi: 10.1046/j.1523-1747.2000.00166.x. PMID: 11121126.;

[12] Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxid Med Cell Longev. 2012;2012:324832. doi: 10.1155/2012/324832. Epub 2012 May 10. PMID: 22666519; PMCID: PMC3359723.;

[13] Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC, Cho KH, Kim KH. The effect of tripeptide-copper complex on human hair growth in vitro. Arch Pharm Res. 2007 Jul;30(7):834-9. doi: 10.1007/BF02978833. PMID: 17703734.;