woman taking care of her skin in front of a mirror

The Do’s and Don’ts: Combining GHK-Cu with Vitamin C in Skincare

Incorporating GHK-Cu (Copper Peptide) and Vitamin C into a skincare routine offers a holistic approach to addressing aging and environmental skin damage. For optimal results, use GHK-Cu in the evening to leverage its collagen-stimulating and skin-rejuvenating properties, and apply Vitamin C in the morning for its antioxidant protection. Avoid mixing them directly to prevent negating their effects. Gradually introduce each ingredient to assess skin tolerance, and consult a dermatologist for personalized guidance tailored to your skin type and needs.

GHK-Cu Peptide Therapy

GHK-Cu is a copper peptide used for its potential anti-aging and regenerative properties. Boost collagen, reduce wrinkles, and restore skin elasticity with this powerful peptide.

In today’s ever-evolving skincare landscape, the strategic combination of GHK-Cu (Copper Peptide) and Vitamin C has become a focal point for those seeking improved skin health. In this article, we will review the principles of combining GHK-Cu and Vitamin C and provide guidance on how to use these ingredients effectively to achieve the most beneficial results.

Overview of GHK-Cu and Vitamin C

GHK-Cu, known for its skin rejuvenation properties, helps stimulate collagen production, thus enhancing skin elasticity.1

Its benefits extend to improving skin texture and reducing the appearance of fine lines, contributing to a more youthful and vibrant appearance.

Vitamin C, on the other hand, is known for its antioxidant properties. It works to defend the skin against the harsh effects of environmental aggressors, playing a crucial role in brightening complexion and promoting a more even skin tone.

woman taking care of her skin in front of a mirror

When GHK-Cu and Vitamin C are used together, they offer a multifaceted approach to skincare, addressing various concerns from aging to environmental damage, making them a powerful duo in any skincare regimen.

Understanding Ingredient Interactions

Understanding the chemical interactions between GHK-Cu and Vitamin C is fundamental to optimizing their use in your skincare routine. Each ingredient differs in pH levels and stability requirements, which means they can negate each other’s effects when mixed directly. In order to create an effective skincare routine that harnesses the strengths of both ingredients, they need to be used at different times of the day.

Seeking advice from a dermatologist or skin care professional is highly recommended, especially for those with sensitive skin. Personalized guidance in crafting your skincare regimen will help ensure you safely and effectively get the most from these potent ingredients.

The Do’s of Combining GHK-Cu with Vitamin C

The key to harnessing the benefits of GHK-Cu and Vitamin C lies in the application timing. Applying GHK-Cu during your evening routine will allow the skin to absorb its rejuvenating properties throughout the night. Using Vitamin C in the morning offers protective barriers against daily environmental stressors, such as the sun.2 This staggered application, when paired with the correct product formulations, helps ensure each ingredient functions optimally without interference.

It’s also important to gauge skin tolerance when introducing both ingredients. Start with lower concentrations and see how your skin responds before gradually increasing the dosage. This kind of gradual approach will help your skin build a tolerance to the products and allow you to decide the most beneficial dosage for your specific needs.

If you aren’t sure what dosage to start with, you may want to see a dermatologist – especially if you have sensitive skin or a skin condition.

The Don’ts of Combining GHK-Cu with Vitamin C

Combining GHK-Cu and Vitamin C requires a cautious approach for the best results. Avoid using these ingredients simultaneously, as their direct mixing can lead to a decrease in their overall effectiveness. Copper peptides oxidize vitamin C and negate its antioxidant properties, effectively canceling out its potential benefits.

Additionally, overuse or high concentrations of GHK-Cu and Vitamin C can lead to skin irritation or sensitization, so be mindful to follow application instructions. Understanding your skin type is essential in tailoring their use to best suit your individual needs, ensuring that you enjoy the maximum benefits without adverse effects.

Professional Advice and Consultation

Consulting with a skincare professional can make a profound difference in your experience. It can be overwhelming to determine what products would be best for your skin type.

A healthcare professional specializing in skin care can evaluate your skin and provide customized recommendations based on your skin condition, concerns, and goals.

This individualized approach is especially important when using strong GHK-Cu and Vitamin C ingredients. A dermatologist can also help you understand how these ingredients interact with your skin and guide you in integrating them into your routine to optimize their benefits while minimizing the risk of adverse reactions.

man washing his face in the bathroom

They can monitor your skin’s response to these ingredients over time, making adjustments as needed to achieve a healthy glow.

Final Thoughts

In summary, while GHK-Cu and Vitamin C are both valuable additions to a skincare regimen, their combined use requires a mindful and educated application. Remember to apply GHK-Cu and Vitamin C at different times of the day to avoid interference with their purposes.

Carefully choose products with compatible formulations, and consider your skin’s tolerance by gradually introducing these new ingredients to your routine. Avoid mixing and overusing them directly, and always consider your unique skin type.

With the right knowledge and approach, the combination of GHK-Cu and Vitamin C can be a powerful ally in your skincare journey, offering a path to a more radiant and healthy complexion.

GHK-Cu Peptide Therapy

As skin ages, collagen and elastin decrease, leading to wrinkles and reduced firmness. GHK-Cu has the potential to increase the formation of these proteins, offering numerous anti-aging benefits such as enhanced wound healing, antioxidant properties, reduced wrinkles, improved skin tone, and overall skin rejuvenation. Embrace your skin's potential. Order now and experience the transformative power of GHK-Cu.

Peptide Shots - Frequently Asked Questions

What is included in our peptide injections?

There are many different peptide injections that we offer as part of a peptide therapy including Sermorelin and PT-141.


Sermorelin is a synthetic form of GHRH (growth hormone-releasing hormone) which controls the hGH (human growth hormone) and it’s recommended to people who have low levels of hGH. 

How do peptides improve your sleep?

Serotonin is a neurotransmitter present in the brain that releases chemicals as messages to your brain and body that it is time to go to sleep. Some peptides can interact with serotonin. Serotonin regulation issues can definitely interfere with a person's ability to have a good night's sleep.

Sermorelin is recognized for their potency as peptides that may potentially enhance sleep.

How do peptides improve immune health?

The immune response can be either blocked or stimulated to produce tolerance using peptides and peptidomimetics as immunomodulating agents.

Read more: Peptide Shots FAQ


[1] Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. PMID: 29986520; PMCID: PMC6073405.;

[2] Al-Niaimi F, Chiang NYZ. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. J Clin Aesthet Dermatol. 2017 Jul;10(7):14-17. Epub 2017 Jul 1. PMID: 29104718; PMCID: PMC5605218.;