vials in different colors in a lab

Which Lab Tests Can Detect Erectile Dysfunction?

Understanding and treating erectile dysfunction (ED) in males necessitates measuring hormones such as testosterone, prolactin, LH, FSH, estradiol, and SHBG which are all a part of our Male and Female Hormone Test. Each of these hormones has a distinct role in men’s health and wellbeing. Knowing more about these hormones allows doctors to develop better treatment strategies that address the underlying causes of ED rather than simply the symptoms, thus improving the health and happiness of individuals affected.

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Erectile dysfunction (ED) is a prevalent but frequently misunderstood disorder that affects many men, with consequences ranging from sexual health to general physical and psychological well-being. Early identification and proper diagnosis of ED are very important for successful management and therapy. Laboratory testing is quite important in this scenario. It gives essential information on the underlying physiological and hormonal aspects that may lead to ED.

vials in different colors in a lab

By detecting hormonal imbalances, metabolic diseases, or other physiological anomalies, these tests allow healthcare practitioners to customize therapy plans that target not just the symptoms but also the underlying reasons of erectile dysfunction. This holistic approach results in a more effective and tailored treatment plan, which improves the quality of life for people afflicted.

Male Hormone and Female Hormone Lab Test

Erectile dysfunction (ED) is a complicated disorder that may be caused by a variety of reasons, including hormone abnormalities. The most closely linked tests in male and female hormone assays for diagnosing probable reasons of erectile dysfunction are:

Testosterone is the prime male sex hormone and serves numerous important functions in sexual health:

Libido (Sex Drive)

Testosterone is needed for a healthy libido.1 Low testosterone levels are frequently connected with a decreased desire in sexual engagement, which can contribute to erectile dysfunction.

Erection Maintenance

Testosterone assists the physiological process of obtaining and sustaining an erection.2 While the direct process is complicated and includes several components (such as the neurological and circulatory systems), good testosterone levels are required for proper erectile function.

Nitric Oxide Synthesis

Testosterone is thought to regulate the body’s synthesis of nitric oxide, a chemical that plays an important part in the relaxation of smooth muscle in the penis, allowing for greater blood flow and erection.3

Psychological Well-being

Testosterone affects mood and general well-being.4 Low levels can cause sadness, anxiety, and a diminished sense of well-being, which can impair sexual performance.

Penile Health

Chronic low testosterone levels might cause structural changes in the penile tissue, potentially exacerbating erectile dysfunction over time.5

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Prolactin testing can be a useful diagnostic tool for erectile dysfunction. The pituitary gland produces prolactin, a hormone that is most usually linked with breastfeeding in females but also plays vital roles in the male body. Here’s why prolactin testing is important in the context of ED:

Hyperprolactinemia and ED

Elevated prolactin levels, also known as hyperprolactinemia, can cause ED.6 High prolactin levels can restrict the release of gonadotropin-releasing hormone (GnRH), resulting in lower testosterone production. Because testosterone is essential for sexual function, this decrease may contribute to erectile dysfunction.

Impact on Libido

Increased prolactin levels can also reduce sexual desire or libido.7 This is because prolactin inhibits dopamine, a neurotransmitter involved in sexual desire and function. Reduced libido can be a major contributor to ED.

Indirect Effects on Erectile Function

Aside from altering libido and testosterone levels, excessive prolactin can have an indirect impact on erectile function. For example, men with hyperprolactinemia may suffer anxiety or sadness as a result of their disease, which can worsen ED.8

Pituitary Gland Disorders

Elevated prolactin levels may suggest pituitary gland diseases, such as a prolactinoma. These disorders can have a variety of impacts on the body, including changes in sexual function.

Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) tests might give useful information in the diagnosis of erectile dysfunction (ED), since both hormones play important functions in the male reproductive system. Here’s why testing for LH and FSH is important in the setting of ED:

Regulation of Testosterone Production

LH is essential for the generation of testosterone in the testes.9 It causes the Leydig cells in the testes to create testosterone. Because testosterone is an important hormone for male sexual function, including desire and the capacity to develop and sustain an erection, variations in LH levels can have a direct influence on erectile function. Low LH levels can cause low testosterone production, which contributes to ED.


FSH is largely important for regulating spermatogenesis, or sperm production. While FSH levels are more directly tied to fertility than erectile function, FSH imbalances might suggest larger abnormalities with the testes or pituitary gland, which may affect sexual health and performance.

Pituitary Gland Function

The pituitary gland produces both LH and FSH. Abnormal levels of these hormones can suggest a problem with the pituitary gland or hypothalamus, which can impair the synthesis of other hormones involved in sexual function.

Hypogonadism Diagnosis

Testing for LH and FSH is very important in detecting various kinds of hypogonadism. Primary hypogonadism, caused by a testicular issue, is characterized by elevated levels of LH and FSH as a result of decreased testosterone feedback. Secondary hypogonadism, caused by a problem with the hypothalamus or pituitary gland, is characterized by low or normal LH and FSH levels. Both disorders can cause low testosterone levels and ED.

Overall Hormonal Health

LH and FSH levels can provide insight into the male body’s overall hormonal health and balance. Hormonal abnormalities can play a key role in erectile dysfunction.

Estradiol testing can be useful in assessing erectile dysfunction (ED) in males, albeit it is frequently less direct than hormones like testosterone. Estradiol, a kind of estrogen, is found in modest levels in males and influences libido, erectile function, and general sexual health. Here’s why estradiol testing is important in the context of ED:

Estradiol and Testosterone Balance

In males, estradiol is produced by the conversion of testosterone. The balance of testosterone and estradiol is very important for sexual function.10 High estradiol levels in relation to testosterone can impair sexual performance and lead to ED.

Impact on Libido

Estradiol affects libido in males as well as women. Abnormally high levels can reduce sexual desire, which is an important aspect of sexual health and may indirectly lead to ED.11

Estradiol's Effect on Erectile Tissue

Some research suggests that estradiol may play a function in the health of erectile tissue.12 However, high quantities of estradiol may have a deleterious influence on this tissue, limiting the capacity to produce or maintain an erection.

Associated Health Conditions

Elevated estradiol levels in males may be related with other health issues such as obesity, liver illness, or thyroid diseases, all of which can impair sexual performance and contribute to ED.

Indicator of Aromatase Activity

High levels of estradiol in males may suggest increased activity of the enzyme aromatase, which transforms testosterone to estradiol.13 This might lead to a reduction in accessible testosterone, affecting sexual function.

Sex Hormone Binding Globulin (SHBG) tests can play an important role in the diagnosis of erectile dysfunction. SHBG is a protein that binds to sex hormones in the circulation, specifically testosterone and estradiol. Understanding the role of SHBG is very important for assessing sexual health and function. Here’s how SHBG testing is relevant in the context of ED.

Regulation of Testosterone Availability

SHBG binds to testosterone, affecting its bioavailability.13 Only a tiny amount of testosterone in the bloodstream is “free” or unbound, which means it is physiologically active and may enter cells to exercise its effects. High levels of SHBG can bind more testosterone, lowering the amount of free testosterone available for the body to use. Because testosterone plays an important role in sexual function, including desire and erectile function, elevated SHBG levels can lead to ED.

Balance Between Testosterone and Estrogen

SHBG also binds to estradiol, which is a kind of estrogen.14 Changes in SHBG levels can disrupt the equilibrium of testosterone and estrogen in the body, which is very important for sexual wellness. Abnormal SHBG levels can upset the equilibrium and contribute to sexual dysfunction.

Indicator of Overall Hormonal Health

Abnormal SHBG levels may suggest problems with general hormonal health. Several variables can affect SHBG levels, including liver function, thyroid hormones, and obesity. High SHBG levels are commonly found in hyperthyroidism and liver illness, whereas low levels are related with obesity, insulin resistance, and hypothyroidism.

Diagnosis of Hypogonadism

In the context of ED, SHBG testing is frequently combined with total testosterone testing. The total testosterone to SHBG ratio can assist in determining whether a man has low bioavailable testosterone, which can lead to a diagnosis of hypogonadism, a cause of erectile dysfunction.


To summarize, the variety of male and female hormone lab testing is very important in understanding the complexity of erectile dysfunction (ED). These tests are not only useful in identifying hormonal abnormalities that may lead to ED, but they also provide a thorough picture of an individual’s hormonal health. Healthcare providers can acquire useful insights into the complex hormonal interactions that govern sexual function by analyzing major hormones such as testosterone, estradiol, prolactin, LH, FSH, and SHBG. This knowledge is very important for developing successful treatment techniques that go beyond symptom alleviation and address the root causes of ED.

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Lab Testing - Frequently Asked Questions

Why is it important to do lab tests occasionally?

It is important to do lab tests occasionally because they can provide valuable information about an individual's health and help to identify potential health issues early on. Lab tests can measure a wide range of factors, including blood count, cholesterol levels, liver and kidney function, and hormone levels, and can provide insight into an individual's overall health and wellness. Additionally, lab tests can help to diagnose and monitor the progression of certain medical conditions, such as diabetes and heart disease, and can help to identify any potential health risks or concerns. By doing lab tests occasionally, individuals can take proactive steps to maintain their health and wellbeing and reduce the risk of potential health problems in the future.

What does a routine blood test cover?

A routine blood test is used to check for a range of things, including your blood count and the levels of certain chemicals and substances in your blood. Blood tests can also be used to check how well certain organs, such as your liver and kidneys, are functioning.

How is a blood sample collected for lab testing?

A blood sample for lab testing is typically collected through a process called venipuncture, which involves inserting a small needle into a vein to draw blood. This is usually done on the inside of the elbow or the back of the hand.

What is the cost of a lab test?

In general, the cost of a lab test can range from a few dollars to several hundred dollars. It is always best to consult with your doctor or healthcare provider to get an accurate estimate of the cost of a lab test.

Read More: Lab Testing FAQ


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[5] Iacono F. - Testosterone deficiency causes penile fibrosis and organic erectile dysfunction in aging men. Evaluating association among Age, TDS and ED;

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[9] Oduwole OO. - The Roles of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Spermatogenesis and Folliculogenesis Revisited;

[10] Kusters CD. - Higher testosterone and testosterone/estradiol ratio in men are associated with better epigenetic estimators of mortality risk;

[11] Chen T. - Different levels of estradiol are correlated with sexual dysfunction in adult men;

[12] Xu ZH. - Effect of estradiol on penile erection: a cross-sectional study;

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[14] Fortunati N. - Sex hormone-binding globulin (SHBG) and estradiol cross-talk in breast cancer cells;