hand of an elderly woman with arthritis

Rheumatoid Arthritis Infusion Therapy – What You Need To Know

Rheumatoid arthritis (RA) infusion therapy provides targeted treatment to reduce inflammation and prevent joint damage. Infusion for RA is the process of delivering medications directly into the bloodstream, providing rapid relief and improving the quality of life for patients who do not respond well to traditional oral medications.

hand of an elderly woman with arthritis

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Types of Infusions for Rheumatoid Arthritis

Biologic infusion for rheumatoid arthritis involves using biologic drugs that target specific parts of the immune system to reduce inflammation and prevent joint damage.1 These infusions for RA are designed to block the action of molecules involved in the inflammatory process, particularly tumor necrosis factor (TNF) or interleukins.

Common biologic drugs include Rituxan, Orencia, and Simponi Aria. These are usually given through an intravenous (IV) infusion in a healthcare setting and can be very effective in managing symptoms for patients who do not respond well to traditional treatments.

Some individuals look to steroid infusions to address symptoms associated with rheumatoid arthritis. This approach utilizes corticosteroids to reduce inflammation and pain in the joints quickly. These infusions deliver a potent dose of steroids directly into the bloodstream, which helps to provide fast relief from severe flare-ups.

Steroid infusions can be very useful during acute episodes of RA when it’s necessary to get symptoms under control quickly. However, they are usually not used as a long-term solution because of some potential side effects like increased blood sugar levels, weight gain, and weakened bones. They are generally used in combination with other treatments to properly manage rheumatoid arthritis.

By administering rheumatoid arthritis medications directly into a vein, IV infusions are a method that ensures the drug is delivered quickly throughout the body. IV for rheumatoid arthritis can include both biologics and steroids, depending on the patient’s specific needs and how severe their condition is.

IV infusion therapy for rheumatoid arthritis is commonly used when oral medications are ineffective or when faster treatment is required. These infusions are usually given in a hospital or clinic but can sometimes be administered at home under medical supervision.

Common Infusion Medications

Rituxan (Rituximab)

Rituxan infusion for rheumatoid arthritis is a therapy type that is used to target and reduce the activity of specific immune cells called B cells. This approach can be helpful for reducing inflammation and preventing joint damage. Rituxan infusion for RA is usually administered through an IV in a clinical setting.

Patients receiving rituximab infusion for rheumatoid arthritis typically require two initial infusions scheduled two weeks apart, followed by maintenance infusions every 24 weeks, depending on their response to the treatment. This therapy has been shown to significantly improve symptoms and quality of life for many patients.

Orencia (Abatacept)

Another biologic treatment that may help manage rheumatoid arthritis is Orencia infusions that inhibit T-cell activation, which plays a crucial role in the inflammatory process of RA.2

Orencia infusions help reduce joint inflammation and delay the progression of the disease and are usually administered through an IV in a clinical setting.  Patients typically receive an initial infusion that lasts 30 minutes, followed by additional infusions at two and four weeks, and then every four weeks after that. This treatment can be very effective in preventing joint damage.

Simponi Aria (Golimumab)

RA infusion Simponi Aria is a biologic therapy used to treat rheumatoid arthritis by targeting and neutralizing tumor necrosis factor (TNF), a substance in the body that causes inflammation. Simponi Aria rheumatoid arthritis treatment is given through a 30-minute IV infusion, usually at weeks zero, four, and then every eight weeks. This schedule helps maintain consistent levels of medication in the body, which can go a long way toward reducing inflammation and improving joint function.

Actemra (Tocilizumab)

Actemra infusion for RA is a biologic medication that targets the interleukin-6 (IL-6) receptor, which plays an important role in the inflammatory process of rheumatoid arthritis. By blocking this receptor, Actemra helps to reduce inflammation, pain, and joint damage. Patients usually receive a 60-minute Actemra infusion for RA once every four weeks through an IV at the doctor’s office, resulting in enhancing the quality of life for many people living with RA.

Remicade (Infliximab)

Designed to target and neutralize TNF, a key contributing factor of inflammation in RA, Remicade infusions involve a 2-hour IV infusion given at weeks zero, two, and six, with subsequent infusions every eight weeks. This treatment helps reduce joint pain, swelling, and long-term damage, providing a considerable amount of relief for many patients who have severe rheumatoid arthritis.3

Methotrexate

Methotrexate infusion for RA is one of the primary treatments for rheumatoid arthritis. This medication works by inhibiting the immune system’s activity, which reduces inflammation and slows the progression of the disease. Methotrexate infusion for RA is usually administered weekly or bi-weekly through an IV, and dosages may vary depending on the needs of the patient, ranging anywhere from 5mg to 30mg per week.

Inflectra (Infliximab)

Highly similar to an already approved biologic medication, Remicade, Inflectra infusions for rheumatoid arthritis work by blocking tumor necrosis factor (TNF), minimizing inflammation, and preventing joint damage. This medication is administered through an IV infusion, typically at zero, two, and six weeks, followed by maintenance infusions every eight weeks. Studies have shown that it is helpful for individuals living with rheumatoid arthritis.4

How Infusion Therapy Works

Infusion therapy for rheumatoid arthritis is the process of administering the medication directly into the bloodstream through an IV. During the infusion, a healthcare provider inserts a small needle into a vein, typically in the arm. The medication is then delivered slowly into the bloodstream over a period ranging from 30 minutes to several hours, depending on the drug.

Infusion therapy for RA is typically done in a clinical setting under the supervision of medical professionals to monitor for any adverse reactions and ensure the treatment is administered properly.

The duration and frequency of infusions vary depending on the specific medication and the patient’s condition. The process generally takes anywhere from 30 minutes to a few hours per session. The frequency of the infusions also varies, as some medications require initial loading doses followed by maintenance doses every few weeks.

For example, a six-month infusion regimen for rheumatoid arthritis refers to medications that need to be administered every six months after the initial loading phase. This schedule helps maintain the therapeutic levels of the medication in the bloodstream and provides long-term, ongoing relief from symptoms.

Infusion therapy can be administered in various locations depending on patient convenience and healthcare systems. These settings are equipped with the necessary medical equipment and staffed by trained professionals who are experienced and can manage the infusion process safely. Some patients may also have the option to receive their infusions at home under medical supervision, which can be more convenient and comfortable.

Benefits of Infusion Therapy

There are several tremendous advantages of infusion therapy for managing rheumatoid arthritis, making it an excellent treatment option. One of the main benefits lies in the fast relief that it provides. By delivering medication directly into the bloodstream, infusion therapy effectively addresses the symptoms related to rheumatoid arthritis and is especially helpful for patients who do not respond well to oral medications.

When attempting to identify the best infusion for rheumatoid arthritis, it is important to note that the most persuasive option varies depending on individual patient needs and their responses to different medications. Biologic infusions, such as Rituxan, Orencia, and Remicade, are often considered among the ideal infusions for rheumatoid arthritis due to their ability to target the immune system specifically.

Additionally, infusion therapies allow for consistent and controlled dosing, which is crucial for managing a chronic condition like rheumatoid arthritis. This consistency helps maintain stable therapeutic levels of the medication, which can help reduce the frequency of flare-ups and the severity of symptoms. Patients also benefit from the regular monitoring that accompanies infusion therapy, which can help ensure that any adverse effects are quickly addressed and that the treatment remains effective.

Side Effects of Infusion Therapy

Recognizing Common Side Effects

The potential for adverse reactions stemming from RA infusions can vary widely depending on the specific medication used. Common RA infusion side effects include headaches, nausea, and fatigue. Some patients might experience a mild rash or itching at the infusion site. Always report any unusual or severe symptoms to your healthcare provider immediately.

Addressing Side Effects

Managing infusion treatment for rheumatoid arthritis side effects involves regular monitoring and ongoing and open communication with your healthcare team. They may pre-medicate you with antihistamines or corticosteroids to minimize reactions. Staying well-hydrated and resting before and after infusions can help reduce feelings of fatigue.

If you experience severe side effects, such as difficulty breathing or chest pain, you must get immediate medical attention. Your healthcare provider will adjust your treatment plan as needed to ensure your safety and comfort during therapy.

Infusion Therapy Pricing

The cost of infusion for rheumatoid arthritis can be quite high, especially for biologic medications. These treatments often require regular administration and specialized medical supervision, which is a contributing factor to their high expense. The RA infusion cost varies depending on the specific medication, the dosage required, and the frequency of the infusions. On average, the price can range from several thousand to tens of thousands of dollars each year.

However, it’s important to note that many drug manufacturers offer payment assistance programs to help manage these costs, especially for those who don’t have private drug insurance coverage. These programs can significantly reduce the financial burden on patients. If you are concerned about the cost of infusion for rheumatoid arthritis, speak with your healthcare provider or the drug manufacturer to explore all of the available assistance options.

FAQs about Rheumatoid Arthritis Infusions

What type of infusions can you get for rheumatoid arthritis?

To treat rheumatoid arthritis, you may receive biologic infusions such as Rituxan, Orencia, Simponi Aria, Actemra, Inflectra, and Remicade. These medications target specific parts of the immune system to reduce inflammation and prevent joint damage. Your doctor can recommend the most suitable option based on your particular condition.

What is a six-month infusion for rheumatoid arthritis?

A 6-month infusion for rheumatoid arthritis refers to medications like Rituxan, which are typically administered every six months after the initial loading doses. This schedule helps maintain the therapeutic effect of the medication and provides consistent and ongoing relief from symptoms.

How long does an RA infusion last?

The duration of a rheumatoid arthritis infusion can vary. Typically, an infusion session lasts between 30 minutes to several hours, depending on the specific medication and the dosage required. Your healthcare provider will give you a more specific time frame based on your treatment plan.

What is the right medication for rheumatoid arthritis?

The most effective drug for rheumatoid arthritis varies from person to person. Biologic medications like Rituxan, Orencia, and Remicade are considered very effective for many patients. The success of these drugs depends on how well they manage symptoms and prevent joint damage in each patient. Your doctor will determine the treatment best suited to meet your unique needs.

Final Words

There are many different benefits of infusion therapy for rheumatoid arthritis, including rapid relief from symptoms and the ability to reduce inflammation and prevent joint damage. There are numerous various types of infusions, such as biologics, steroids, and IV medications, which can provide targeted treatment options.

Medications like Rituxan, Orencia, Simponi Aria, Actemra, Inflectra, Remicade, and Methotrexate are commonly used to manage RA. Each type of infusion therapy is administered with precise dosing and regular monitoring to ensure the best outcomes for patients.

Infusion therapy for rheumatoid arthritis provides an excellent method to manage severe symptoms and improve the quality of life for many patients. If traditional oral medications are not providing proper relief, discussing infusion therapy for RA with your healthcare provider is highly recommended.

This therapy can offer significant improvements in joint function, reduce pain, and help slow disease progression, helping you maintain a more active and fulfilling life.

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Vitamin IV Therapy - Frequently Asked Questions

What is IV therapy, and how does it work?

IV therapy is a process in which fluids, vitamins, minerals, and/or medications are administered into the bloodstream via a catheter. The catheter is inserted into a blood vein, the IV infusion bag is hung over the patient’s head, and gravity slowly drips the contents of the bag into the patient’s bloodstream.

Who can benefit from IV therapy?

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What types of IV therapy treatments are available?

Drip Hydration offers a wide range of IV treatment options. Our IV infusions contain vitamins, fluids, minerals, electrolytes to help address many health and wellness targets.

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What are the benefits of IV therapy?

IV therapy offers many potential wellness benefits, including:

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References

[1] Patel JP, Konanur Srinivasa NK, Gande A, Anusha M, Dar H, Baji DB. The Role of Biologics in Rheumatoid Arthritis: A Narrative Review. Cureus. 2023 Jan 3;15(1):e33293. doi: 10.7759/cureus.33293. PMID: 36606106; PMCID: PMC9808655.;

[2] Weyand CM, Bryl E, Goronzy JJ. The role of T cells in rheumatoid arthritis. Arch Immunol Ther Exp (Warsz). 2000;48(5):429-35. PMID: 11140470.;

[3] Melsheimer R, Geldhof A, Apaolaza I, Schaible T. Remicade® (infliximab): 20 years of contributions to science and medicine. Biologics. 2019 Jul 30;13:139-178. doi: 10.2147/BTT.S207246. PMID: 31440029; PMCID: PMC6679695.;

[4] Thorne C, Bensen WG, Choquette D, Chow A, Khraishi M, Atkins CJ, Kelsall JT, Lehman AJ, Shawi M, Khalil H, Nantel F, Rampakakis E, Sampalis JS, Otawa S. Effectiveness and safety of infliximab in rheumatoid arthritis: analysis from a Canadian multicenter prospective observational registry. Arthritis Care Res (Hoboken). 2014 Aug;66(8):1142-51. doi: 10.1002/acr.22290. PMID: 24470077.;