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Can Trazodone Be Used As A Hangover Medication?

Trazodone is a prescription medication that is typically used to treat depression. It can help to improve mood, increase appetite, and support energy levels. It has also been found to decrease feelings of anxiety and prevent insomnia that is caused by depression. Trazodone has also been used for other purposes as well, including as a hangover cure.

This article will share more about Trazodone as a hangover cure and how it works.

How Trazodone works

Trazodone works by balancing out certain chemicals in the brain. This medication works by increasing levels of serotonin and noradrenaline to help people who have depression feel better. Trazodone falls into a class of medications called serotonin modulators.

Trazodone is typically used as a second-line treatment for depression, so it is prescribed when other antidepressants have been used without success.

photo of brain

Does trazodone work for hangovers?

Trazodone is not typically prescribed for hangovers; you should only use it as your doctor directs. Further, Trazodone has not been studied for its effect on hangovers, and some individuals who have used it report that Trazodone itself may cause a hangover after being used.

Studies relating to trazodone and alcohol use focus more on alcohol withdrawal symptoms in detoxing patients, not hangover treatment.

Trazodone has been studied for its use as a treatment for alcohol withdrawal and for helping with sleep disturbances related to alcohol detoxification. One study found that Trazodone was a successful treatment for preventing alcohol withdrawal symptoms during detox.1 When a person struggles with alcohol abuse, they can experience uncomfortable and dangerous symptoms while their body detoxes from the alcohol. Trazodone might be able to help with these symptoms.

Another study looked at Trazodone as a method to help improve sleep quality in people detoxing from alcohol.2 Alcohol can cause poor sleep, and the goal of this study was to look at how Trazodone could help improve sleep quality in the individuals who were studied. This study found that Trazodone could provide short-term improvement in sleep quality, but the safety and efficacy of it still need further research.

What is a typical dosage of Trazodone?

A typical adult dosage of Trazodone is between 50 and 200 milligrams per day. This dosage may be adjusted over time depending on how your body adjusts. Trazodone should not be combined with certain medications, so it is important to tell your doctor if you are taking any other medications before starting the use of Trazodone. Other precautions when taking Trazodone include:

  • Tell your doctor if you are pregnant or plan to become pregnant
  • Before having surgery, make sure to inform your doctor that you are taking Trazodone
  • Do not combine alcohol and Trazodone since alcohol can worsen the side effects of Trazodone.
  • Trazodone can cause glaucoma.

Trazodone does have the potential to cause certain side effects. Some examples include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Appetite changes
  • Weakness
  • Fatigue
  • Nervousness
  • Muscle pain
  • Rash
  • Decreased sex drive
  • Shakiness

Although less likely, more serious side effects can occur when taking Trazodone. Serious side effects that warrant immediate medical attention include:

  • Chest pain
  • Irregular heart rate
  • Loss of consciousness
  • Fainting
  • Seizures
  • Nosebleeds
  • Fever
  • Confusion
  • Poor coordination

If you think you are having a serious reaction, you should seek medical care immediately. Trazodone has the potential to cause serious and dangerous side effects. This medication has provided some positive benefits for some patients who take it for depression. However, it is best not to take medication for off-label usage, like a hangover treatment.


Trazodone is an effective medication that is used as an antidepressant. Trazodone is typically prescribed to patients who have tried one antidepressant without having positive results. The effects of Trazodone are achieved by balancing out certain chemicals in the brain. Trazodone is considered a serotonin modulator, meaning it affects the brain’s serotonin amount.

Trazodone has not been studied as a hangover treatment and is not prescribed for this purpose. Some studies have evaluated trazodone and alcohol use by evaluating how it helps addicts with withdrawal symptoms. It is best to only use Trazodone as your doctor has prescribed it since serious and dangerous side effects are possible.

Get Your Hangover IV

Recover from a big night out with our hangover IV. This treatment helps relieve hangover symptoms by rehydrating, restoring, and replenishing your body. Infusions take less than an hour and are administered by one of our licensed nurses.

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Hangover IV - Frequently Asked Questions

What is included in our hangover IV?

Our Hangover IV treatment contains a blend of IV fluids, electrolytes, vitamins and medication to restore the vitamins in your body and help your body battle with the unwanted hangover symptoms. Among the main ingredients are B-Complex vitamins, Vitamin B12, Toradol and Anti-Nausea medication. 

Why is hangover IV much more effective than hangover drinks?

Hangover IV is more effective than hangover drinks because the IV solution is introduced directly into your blood without having to go through the digestive system which is already overloaded. This means you will feel the effects much faster and feel much better very quickly. 

How long does it take for our Hangover IV to start working?

It usually takes between 30-60 minutes for you to feel the benefits of our Hangover IV drip.

What are the levels of hangover severity?

IV therapy in general is FDA approved. Our nurses are overseen by our Medical Director, Abe Malkin, and every nurse is registered and certified per state standards.

Read more: Hangover IV FAQ


[1] Borras L - Successful treatment of alcohol withdrawal with trazodone.;

[2] Friedmann PD - Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial.;