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Are There Any Side Effects Of Using Glutathione Supplements And IV?

Glutathione supplements and IVs detoxify the body and support liver function. Still, you may be surprised at the number of side effects glutathione can cause if not administered by a medical professional.

So, is glutathione safe and worth it? Here is what you need to know about the possible glutathione side effects and which option is best for your specific needs.

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Why People Use Glutathione Supplements

Although we hear more and more about glutathione, there’s still a lot of confusion over what it is and why people would use glutathione supplements. It can be hard to separate fact from fiction. Let’s start with answering: What is glutathione? Glutathione refers to a class of antioxidants containing cysteine, which studies have shown to help prevent cancer and protect cells.

We hear about glutathione in relation to antioxidants. So, why do people use glutathione supplements? The primary reason is its role as an antioxidant. Antioxidants protect your cells from oxidative stress done by free radicals which have an imbalanced number of electrons (and hence are highly reactive). But antioxidants aren’t readily available in our food, which is one reason why people are turning to glutathione pills and tablets.

Another reason is that glutathione levels fall naturally as we age, further exposing aging cells to oxidative stress.1 By supplementing glutathione, you can help your body preserve the levels necessary to maintain protection against free radicals.

It should be noted that glutathione IV therapy is more effective for supplementation and absorption because it bypasses the digestive process. Glutathione is very easily broken down during the digestive process, leading to a lower absorption rate. This means that your body is not able to use 50% or more of the glutathione dose you consumed orally. Glutathione drip therapy, however, delivers glutathione directly to the bloodstream, ensuring an absorption rate of 95% or more. This helps ensure you get the maximum benefit of supplementation; plus, IV drip can begin working right away since they do not have to pass through your digestive system first.

On a cellular level, glutathione helps protect against:

  • Cancer
  • Fights cell aging
  • Boosts your immune system
  • Regulates inflammation
  • Improves your mood
  • Enhances your memory
  • Stabilizes blood sugar levels

It’s nature’s all-star supplement.

In addition to combating oxidative stress, glutathione is used for several body functions including enzyme activation, metabolic processes, DNA creation and repair, and the production of proteins. Glutathione also helps detoxify the body, helping to break down and flush naturally created chemicals, substances, and pollutants.

Supplementing with glutathione IV therapy may:

  • Help relieve psoriasis symptoms
  • Help reduce cell damage associated with fatty liver disease
  • Improve symptoms of several conditions, including autoimmune disorders, Parkinson’s disease, diabetes, and other conditions
  • Improve insulin resistance that has declined due to age

Glutathione deficiency has been linked to Covid-19, meaning that researchers believe people who do not get enough glutathione are at higher risk of getting infected, as well as more likely to develop severe symptoms. Covid-19 has also shown to alter glutathione generation patterns related to aging. It appears younger people who get Covid-19 are showing signs of oxidant damage typically seen in much older age groups. Supplementing glutathione after being infected by Covid-19 may help reduce symptoms and help you heal faster. It may also help relieve long-term Covid effects.

How does Glutathione Works?

First, glutathione is converted into glutathione disulfide (GSSG) by glutathione reductase. This reduces both extracellular free radicals and peroxides to water before damaging cells.

four different kind of pills in four different spoons.

Glutathione’s antioxidant properties help prevent many degenerative diseases associated with oxidative stress, including cancer. Secondly, glutathione is a powerful agent that protects cells from damage by free radicals, which are highly reactive molecules with unpaired electrons. Since these unstable compounds strongly attract other molecules with an electron to pair up, they can damage proteins, DNA, and lipids. This can result in decreased metabolic efficiency or even cell death (apoptosis). It has been shown that oxidative stress contributes to more than 75 percent of all degenerative diseases.2

Glutathione Side Effects

Glutathione is a powerful antioxidant that helps support your immune system. If you’re wondering about the side effects of glutathione, it’s a good idea to consult your doctor before taking glutathione. But fortunately, there aren’t many side effects to worry about as long as you use recommended dosages. Dosage can vary case-by-case and is dependent on the different factors that may impact your glutathione levels. You may notice some temporary discomfort, but that typically subsides within a few days as your body adapts to glutathione. Let’s see through which delivery option is glutathione safe.

Some of the side effects and health risks of supplementing glutathione include:

Inhaled glutathione supplements have been linked to asthma attacks. Other forms of glutathione supplementation also may cause bronchial constriction. If you have asthma, you should discuss glutathione with your medical provider before taking any supplements. You should also familiarize yourself with asthma attack symptoms, such as wheezing.

Some people may develop a rash or other symptoms of an allergic reaction after taking glutathione.

Supplementing glutathione long-term has been associated with having low zinc levels. If you already have a zinc deficiency, you should discuss if you should take glutathione with your doctor.

People who are breastfeeding or pregnant should avoid glutathione supplements, as there is not enough research to establish its safety. Currently, there are not any known severe medication interactions. However, there are many medications that are known to have mild interactions with glutathione. Make sure you consult with your doctor about what to avoid when taking glutathione IV treatment or other supplements that include glutathione.

If you’re wondering about the long-term glutathione side effects, your doctor may recommend slowly increasing your dosage over time to ensure your body doesn’t experience any adverse reactions. It’s also important to remember that everyone responds differently to glutathione. The best way to avoid possible side effects of glutathione is by sticking with what works for you. If one dose doesn’t seem enough, it could be worth trying a different brand or supplement altogether.

You can also talk to your doctor about whether or not you should take glutathione with certain medications. For example, if you’re taking medication for diabetes, it may be best to avoid taking glutathione alongside it. While most people experience few side effects when taking glutathione, one possible adverse effect is upset stomach if taken in high doses. Contact your doctor if you think you’re experiencing side effects from glutathione supplements.

Side Effects of Different Glutathione Treatments

Intravenous glutathione has few side effects. However, intravenous use can cause redness, itching, and irritation at injection sites. Most of these side effects are linked to any kind of IV therapy or treatment. Patients may also feel a little tired after an infusion is complete. Intravenous use is relatively low risk so if your question was “Is Glutathione safe?” the answer is that it is mostly safe. In rare cases, patients have had allergic reactions as part of the glutathione drip side effects that people reported.

There are not much information and research on these side effects when it comes to taking glutathione tablets and pills. But in high doses, doctors warn that it could be toxic for your liver. Just keep to the recommended dose that your doctor prescribed, and you will be safe.

Glutathione injection shots side effects may include:

Taking glutathione supplements may result in abdominal cramps or bloating.

Reducing the Risk of Side Effects

While there is the potential to experience some side effects when using glutathione supplements, there are several steps you can take to help reduce your risk.

Ways to reduce your risk of side effects associated with Glutathione include:

  • Speaking with your doctor before using supplements
  • Begin with a lower dosage and gradually increase the amount
  • Monitoring your body’s response before adjusting your dosage
  • Talk with your doctor about whether this is a safe option for you before beginning any supplement regimen.

Your doctor can review your medical history and any current medications you are taking to help determine if glutathione supplements are safe for you.

Questions to ask your doctor before trying Glutathione include:

  1. Is Glutathione a suitable option for me?
  2. What is a safe dosage of Glutathione?
  3. What types of side effects should I watch out for?
  4. Are there any risks of severe reactions when taking Glutathione?

You can also reduce your risk of side effects by starting with a lower dosage and gradually increasing it. Noticeable side effects after supplementation or through a glutathione IV may indicate the need for a lower dosage in the future. When a larger dosage is recommended, a gradual increase is crucial to help gauge how your body reacts to the new dosage before increasing it further.

Working with a trusted medical professional can help you determine the best dosing strategy.

Pay close attention to how your body reacts to Glutathione. If you are noticing side effects after beginning with a low dosage, increasing your dosage is not recommended. Always work closely with your healthcare provider to help you determine the appropriate dosage, and openly discuss how you are feeling so they can provide the best recommendations.

When is IV the best option?

Contact our offices and our team of medical professionals led by founders Dr. Abe Malkin and Dr. Neal Kumar, will answer your queries.

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Safety Precautions and Contraindications

As with any supplement, you should exercise caution when taking Glutathione. Some people have sensitivities to Glutathione and may experience side effects or an allergic reaction when taking it. If you notice these issues, you may need to discontinue usage of it.

Glutathione is also available through inhalation. Individuals who have asthma should consult with their doctor to help determine if they have sensitivities to this treatment, as inhaled Glutathione may trigger an asthma attack.

Always consult with your doctor about any medications and supplements you are currently taking so they can best determine if Glutathione is safe for you. Even natural supplements can potentially interact with each other, so clearly share all of the medications and supplements you are currently taking with your physician.

Only take Glutathione supplements or injections under the guidance of a skilled healthcare professional who can help you navigate through the process. Having a qualified provider present allows you to be aware of any side effects to look out for, and they can also help you determine whether any side effects are a cause for concern or not.

At-home Mobile IV Treatment

If you want to reap all these benefits of glutathione without having to take a pill, drink several shots of glutathione or self-inject with glutathione supplements, then at-home mobile IV treatments offer an effective way to replenish your body’s glutathione levels at whatever location of your desire or on the go.

Mobile IV drip therapy provides a convenient alternative for those who want to take glutathione without any adverse reactions.

A mobile IV can be delivered in a matter of minutes, making it possible to replenish your body’s glutathione levels without having to visit a clinic or hospital for a full hour-long treatment. You can schedule a mobile IV treatment wherever you are, allowing you to take advantage of your busy lifestyle as you maintain optimal health. Drip Hydration offers mobile IV therapy throughout the country. With locations across most major US cities, professional staff, and top-of-the-line treatment options, they should always be a go-to when it comes to glutathione IV therapy. If you’re under the weather or anticipating a rough night ahead, their mobile IV will come to you, whether it’s your office or home. The convenience of your location and schedule is enough to convince most people alone. Give Drip Hydration a call today to get you feeling better tomorrow!

Summary and Key Takeaways

It is possible to experience some side effects from taking Glutathione. Some of these side effects may vary depending on whether the medication is ingested orally, through an IV, or as an injection. IV glutathione is generally associated with minimal risks and is considered safe.

It is important to first weigh out the risks versus the benefits before starting to use Glutathione. If you notice side effects from Glutathione, you may be sensitive to it. Sensitivity typically requires discontinuing usage or lowering your dosage.

Only take Glutathione with the guidance of a healthcare professional who can make the process seamless since they can help identify any side effects and answer any questions you have.

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Glutathione - Frequently Asked Questions

What is glutathione?

Glycine, cysteine, and glutamic acid are the building blocks for the compound glutathione. It is created by the liver and is used by several bodily functions. Glutathione helps with the production of chemicals and proteins required by the body, as well as immune system activity.

What are the benefits of taking glutathione?

Taking glutathione has many benefits including:

  • Reducing oxidative stress
  • Reducing cell damage in alcoholic and nonalcoholic liver disease
  • Improves insulin resistance in older people
  • Increase mobility for people with peripheral artery disease
  • Reduces symptoms of Parkinson’s disease
  • Might help fight autoimmune diseases
  • Might reduce oxidative damage in children with autism
  • Might reduce the impact of uncontrolled diabetes
  • Might reduce respiratory disease symptoms
  • Might improve psoriasis

Glutathione IV Therapy vs supplements

Glutathione supplementation has been related to digestive problems, such as bloating or stomach cramps. Intravenous glutathione provides the antioxidant directly to your cells by totally avoiding the digestive system.

Does glutathione help reduce oxidative stress?

According to one research, glutathione either increases or decreases the body's immune response, which helps alleviate oxidative stress. Diseases with an autoimmune component damage particular cells' mitochondria. By scavenging free radicals, glutathione protects the mitochondria of the cell.


[1] Betteridge DJ. - What is oxidative stress? Metabolism.;

[2] Uttara B, Singh AV, Zamboni P, et al. - Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol.;