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Are There Any Side Effects Of Using Glutathione Supplements And IV?

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Glutathione supplements and IVs detoxify the body and support liver function. Still, you may be surprised at how many side effects glutathione can cause if not administered by a medical professional. These two options offer some of the same benefits, so here’s what you need to know about the possible glutathione side effects and which option is best for your specific needs.

Why People Use Glutathione Supplements

Although we hear more and more about glutathione, there’s still a lot of confusion over what it is and why people would use glutathione supplements. It can be hard to separate fact from fiction. Let’s start with answering: What is glutathione? (Glutathione refers to a class of chemicals containing cysteine, which studies have shown to help prevent cancer and protect cells.)

We hear about glutathione in relation to antioxidants. So, why do people use glutathione supplements? The primary reason is its role as an antioxidant. (Antioxidants are like vitamins for your cells.) But antioxidants aren’t readily available in our food, which is one reason why people are turning to glutathione pills and tablets.

Another reason is that glutathione levels fall naturally as we age, further exposing aging cells to oxidative stress.1 By supplementing glutathione, you can help your body preserve the levels necessary to maintain protection against free radicals.

It should be noted that IV therapy is more effective for glutathione supplementation because it bypasses the digestive process. Glutathione is very easily broken down during the digestive process, leading to a low absorption rate. This means that your body is not able to use 50% or more of the glutathione dose you consumed orally. Glutathione infusion therapy, however, delivers glutathione directly to the bloodstream, ensuring an absorption rate of 90% or more. This helps ensure you get the maximum benefit of supplementation; plus, IV infusions can begin working right away since they do not have to pass through your digestive system first.

On a cellular level, glutathione helps protect against:

blonde girl getting iv therapy
  • Cancer
  • Fights cell aging
  • Boosts your immune system
  • Regulates inflammation
  • Improves your mood
  • Enhances your memory
  • Stabilizes blood sugar levels

It’s nature’s all-star supplement.

In addition to combating oxidative stress, glutathione is used for several body functions including enzyme activation, metabolic processes, DNA creation and repair, and the production of proteins. Glutathione also helps detoxify the body, helping to break down and flush naturally created chemicals, substances, and pollutants.

Supplementing with glutathione IV therapy may:

  • Help relieve psoriasis symptoms
  • Help reduce cell damage associated with fatty liver disease
  • Improve symptoms of several conditions, including autoimmune disorders, Parkinson’s disease, diabetes, and other conditions
  • Improve insulin resistance that has declined due to age

Glutathione deficiency has been linked to Covid-19, meaning that researchers believe people who do not get enough glutathione are at higher risk of getting infected, as well as more likely to develop severe symptoms. Covid-19 has also shown to alter glutathione generation patterns related to aging. It appears younger people who get Covid-19 are showing signs of oxidant damage typically seen in much older age groups. Supplementing glutathione after being infected by Covid-19 may help reduce symptoms and help you heal faster. It may also help relieve symptoms of long-Covid.

pills in spoons

How Does It Work?

First, glutathione is converted into glutathione disulfide (GSSG) by glutathione reductase. This reduces both extracellular free radicals and peroxides to water before damaging cells. Glutathione’s antioxidant properties help prevent many degenerative diseases associated with oxidative stress, including cancer.

Secondly, glutathione is a powerful agent that protects cells from damage by free radicals, which are highly reactive molecules with unpaired electrons. Since these unstable compounds strongly attract other molecules with an electron to pair up, they can damage proteins, DNA, and lipids. This can result in decreased metabolic efficiency or even cell death. It has been shown that oxidative stress contributes to more than 75 percent of all degenerative diseases.2

Glutathione Side Effects

Glutathione is a powerful antioxidant that helps support our immune system. If you’re wondering about the side effects of glutathione, it’s a good idea to consult your doctor before taking glutathione. But fortunately, there aren’t many side effects to worry about as long as you use recommended dosages. Dosage can vary case-by-case and is dependent on the different factors that may impact your glutathione levels. You may notice some temporary discomfort, but that typically subsides within a few days as your body adapts to glutathione.

Some of the side effects and health risks of supplementing glutathione include:

man holding his stomach and chest near his heart
  • Can trigger asthma attacks- Inhaled glutathione supplements have been linked to asthma attacks. Other forms of glutathione supplementation also may cause bronchial constriction. If you have asthma, you should discuss glutathione with your medical provider before taking any supplements. You should also familiarize yourself with asthma attack symptoms, such as wheezing.
  • Allergic reaction- Some people may develop a rash or other symptoms of an allergic reaction after taking glutathione.
  • Zinc deficiency- Supplementing glutathione long-term has been associated with having low zinc levels. If you already have a zinc deficiency, you should discuss if you should take glutathione with your doctor.
  • Bloating and cramps- Taking glutathione supplements may result in abdominal cramps or bloating.
    People who are breastfeeding or pregnant should avoid glutathione supplements, as there is not enough research to establish its safety. Currently, there are not any known severe medication interactions. However, there are many medications that are known to have mild interactions with glutathione. Make sure you consult with your doctor about what to avoid when taking glutathione IV or other supplements that include glutathione.

If you’re wondering about the long-term glutathione side effects, your doctor may recommend slowly increasing your dosage over time to ensure your body doesn’t experience any adverse reactions. It’s also important to remember that everyone responds differently to glutathione. The best way to avoid possible side effects of glutathione is by sticking with what works for you. If one dose doesn’t seem enough, it could be worth trying a different brand or supplement altogether.

You can also talk to your doctor about whether or not you should take glutathione with certain medications. For example, if you’re taking medication for diabetes, it may be best to avoid taking glutathione alongside it. While most people experience few side effects when taking glutathione, one possible adverse effect is upset stomach if taken in high doses. Contact your doctor if you think you’re experiencing side effects from glutathione supplements.

Glutathione IV Side Effects

Intravenous glutathione has few side effects. However, intravenous use can cause redness, itching, and irritation at injection sites. Patients may also feel a little tired after an infusion is complete. Intravenous use is relatively low risk so if your question was “Is Gluta drip safe?” the answer is that it is mostly safe. In rare cases, patients have had allergic reactions as part of the gluta drip side effects that people reported.

nurse preparing an IV bag at home
pills and capsules

Glutathione Tablets Side Effects

There are no reported side effects when it comes to taking glutathione tablets and pills. But in high doses, doctors warn that it could be toxic for your liver. Just keep to the recommended dose that your doctor prescribed and you will be safe.

Glutathione Injection Side Effects

Glutathione injections side effects may include:

  • Skin rash
  • Allergic reaction
  • Los of hair
  • Nausea
two injections
  • Diarrhea or upset stomach
  • Chest pain
  • Breathing problems
  • Pain in breasts
  • Eye disorder
  • Whitening of hair
  • Gain in weight
  • Aggravate symptoms of asthma
  • Steven Johnson’s syndrome
  • Numbness
  • Toxic epidermal necrosis

Mobile IV Treatment

If you want to reap all these benefits of glutathione, but without having to take a pill or drink several shots of glutathione, mobile IV treatments offer an effective way to replenish your body’s glutathione levels at home or on the go.

Mobile intravenous therapy provides a convenient alternative for those who want to take glutathione without any adverse reactions. A mobile IV can be delivered in a matter of minutes, making it possible to replenish your body’s glutathione levels without having to visit a clinic or hospital for a full hour-long treatment. You can schedule a mobile IV treatment wherever you are, allowing you to take advantage of your busy lifestyle as you maintain optimal health.

Companies like Drip Hydration offers mobile IV therapy throughout the country. With locations across most major US cities, professional staff, and top-of-the-line treatment options, they should always be a go-to when it comes to glutathione IV therapy. If you’re under the weather or anticipating a rough night ahead, their mobile IV will come to you, whether it’s your office or home. The convenience of your location and schedule is enough to convince most people alone. Give Drip Hydration a call today to get you feeling better tomorrow!

Get An Easy, At-Home Glutathione Treatment With Drip Hydration

If you are interested in upping your general wellness with glutathione therapy, Drip Hydration can help. With a call or click, one of our Registered Nurses can come to your home and administer one of our 12 specially-blended formulas, along with a glutathione push.

Our services help you work towards general wellness goals without unnecessarily exposing yourself and your household to the Covid-19 Delta Variant. Our IV memberships include complimentary medical phone consultations, priority booking, and discounted access to our Nutritional Lab Tests.

We’re excited to work with you to make sure your body has the fuel it needs to function at its best. Book an appointment with us today!


[1] Betteridge DJ. - What is oxidative stress? Metabolism.;

[2] Uttara B, Singh AV, Zamboni P, et al. - Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol.;