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What Are The Benefits of Combining NAC And Glutathione?

This potent combination of antioxidants bolsters the body’s inherent mechanisms to combat oxidative stress, boosts immune system efficacy, and mitigates inflammation.(1,2) Collectively, they enhance the process of liver detoxification, perhaps enhance athletic performance, and may have neuroprotective benefits, aiding in the prevention of neurodegenerative diseases such as Parkinson’s and Alzheimer’s.(3,4) In addition, this combination can improve the functioning of mitochondria, leading to enhanced physical and cognitive performance.5 It also aids in the repair of DNA and boosts energy levels, resulting in superior overall health results compared to taking each supplement alone.6

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A powerful antioxidant included in various treatments like Immune Boost IV and Super Immune Boost IV, that boosts the immune system, supports energy, and improves mood.

Do you ever feel overwhelmed and exhausted? Have you been looking for ways to improve your overall health and well-being? If so, you may have heard of NAC (N-acetyl cysteine) and glutathione, two supplements that are becoming increasingly popular. In this blog post, we’ll explore what NAC and glutathione are and the potential benefits of combining them. We will also address potential side effects. Read on to learn more about these two supplements and how they could help you improve your overall health and well-being!

What are NAC and glutathione?

N-Acetyl Cysteine (NAC) is an antioxidant supplement derived from the amino acid cysteine. It has several beneficial effects on the body, including reducing oxidative stress, boosting the immune system, and helping to detoxify the liver. NAC also helps break down mucus in the lungs and reduce inflammation, making it a popular supplement for respiratory illnesses.

healthcare professional looking at a tablet

Glutathione is a powerful antioxidant and one of the body’s main defense systems against disease and aging. It works by neutralizing free radicals, which are molecules that can cause damage to cells in the body. It also helps to reduce inflammation, protect the liver from toxins, and boost the immune system. The body naturally produces glutathione, but supplementation can enhance its production.

Infusion therapy is a method of administering NAC and glutathione intravenously. With this method, a small amount of each supplement is mixed with saline fluids and injected into the bloodstream through a vein. This allows for rapid absorption of the supplements so their benefits can be felt more quickly than if taken orally.

Combining NAC and glutathione infusion therapies could offer several potential health benefits. These two powerful antioxidants work together to support the body’s natural defenses against oxidative stress, improve immunity, reduce inflammation, and detoxify the liver. Taking both together may improve overall health outcomes compared to taking either one alone.

Additionally, this combination may help improve athletic performance, as NAC and glutathione are known to aid recovery after exercise. A combined NAC and glutathione infusion therapy may have neuroprotective properties and could help prevent neurodegenerative diseases such as Parkinson’s and Alzheimer’s.

What are the benefits of NAC and glutathione supplementation?

NAC (N-acetylcysteine) and Glutathione are two naturally-occurring compounds that offer a variety of health benefits. NAC is essential for your body to create the antioxidant glutathione.

woman consulting with a doctor

Glutathione helps to protect cells from damage caused by free radicals, oxidative stress, and other toxins. NAC is also beneficial in its own right. NAC has been studied for its beneficial effects in several areas, including respiratory illnesses, mental health, heart health, and cancer. Studies suggest that NAC may help reduce the risk of COPD flare-ups in people with chronic obstructive pulmonary disease (COPD), reduce symptoms of depression, reduce inflammation and the risk of heart attack and stroke, and reduce the risk of some types of cancer.7

The potential benefits of combining NAC and glutathione are just beginning to be explored. Combining these compounds may offer synergistic benefits, such as:

  • Reducing inflammation throughout your body
  • Supporting healthy DNA repair and help reduce oxidative damage caused by free radicals
  • May improve mitochondrial function, enhancing physical performance and cognitive function
  • Providing immune system support
  • Balance inflammatory pathways, making it a great choice for those suffering from chronic inflammation or autoimmunity issues
  • Can support healthy energy levels, improved mood regulation, and emotional well-being.

Overall, the combination of NAD+ and Glutathione can provide many powerful health benefits and improved quality of life. As research continues to explore the potential benefits of this combination, we are likely to discover even more ways in which NAC and glutathione can improve our health.

In addition to boosting antioxidants, combining NAC and glutathione may have an additional benefit – increasing NAD+ levels. NAD+ is essential for healthy cell function, and boosting NAD+ through supplementation or infusions has been linked to anti-aging and improved energy levels. Therefore, adding NAC to existing NAD+ treatments or infusions could provide a layer of support for cellular function.

Is NAC and glutathione supplementation safe?

NAC and glutathione supplementation is generally safe when administered by a licensed healthcare professional. However, potential side effects may include nausea, vomiting, headaches, and dizziness. Additionally, those with liver or kidney disease should not take NAC or glutathione supplementation due to the potential for worsening existing conditions.

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It’s imperative to seek NAC and glutathione IV therapy from a licensed and trained healthcare professional, as they can determine if supplementation is right for you. A reliable doctor will also conduct a health screening before administering treatment, which may include blood tests and medical history to ensure the therapy is safe and effective.

By combining NAC and glutathione in an IV therapy, patients might experience many benefits. Most notably, this combination of antioxidants may help reduce oxidative stress that leads to cell damage. NAC and glutathione might support the body’s natural detoxification process by binding to toxins, making them less harmful or easier to eliminate. Furthermore, this combination can possibly increase energy levels and improve mental clarity while providing powerful protection against free radical damage.

Final thoughts

NAC and glutathione are powerful antioxidants that may have numerous health benefits when taken in IV therapy. While the effects of combined NAC and glutathione therapy have not been extensively studied, those who have used it may feel better overall with fewer side effects than traditional forms of therapy. With the help of a licensed and trained healthcare professional, NAC and glutathione IV therapy may offer many health benefits. However, it is important to remember that everyone responds differently to supplementation, so it is always best to speak to your doctor before beginning any new treatment plan.

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Glutathione - Frequently Asked Questions

What is glutathione?

Glycine, cysteine, and glutamic acid are the building blocks for the compound glutathione. It is created by the liver and is used by several bodily functions. Glutathione helps with the production of chemicals and proteins required by the body, as well as immune system activity.

What are the benefits of taking glutathione?

Taking glutathione has many benefits including:

  • Reducing oxidative stress
  • Reducing cell damage in alcoholic and nonalcoholic liver disease
  • Improves insulin resistance in older people
  • Increase mobility for people with peripheral artery disease
  • Reduces symptoms of Parkinson’s disease
  • Might help fight autoimmune diseases
  • Might reduce oxidative damage in children with autism
  • Might reduce the impact of uncontrolled diabetes
  • Might reduce respiratory disease symptoms
  • Might improve psoriasis

Glutathione IV Therapy vs supplements

Glutathione supplementation has been related to digestive problems, such as bloating or stomach cramps. Intravenous glutathione provides the antioxidant directly to your cells by totally avoiding the digestive system.

Does glutathione help reduce oxidative stress?

According to one research, glutathione either increases or decreases the body's immune response, which helps alleviate oxidative stress. Diseases with an autoimmune component damage particular cells' mitochondria. By scavenging free radicals, glutathione protects the mitochondria of the cell.


[1] Kerksick C, Willoughby D. The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress. J Int Soc Sports Nutr. 2005 Dec 9;2(2):38-44. doi: 10.1186/1550-2783-2-2-38. PMID: 18500954; PMCID: PMC2129149.;

[2] Sakai M, Yu Z, Taniguchi M, Picotin R, Oyama N, Stellwagen D, Ono C, Kikuchi Y, Matsui K, Nakanishi M, Yoshii H, Furuyashiki T, Abe T, Tomita H. N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling. Int J Mol Sci. 2023 Feb 14;24(4):3798. doi: 10.3390/ijms24043798. PMID: 36835209; PMCID: PMC9968039.;

[3] Khoshbaten M, Aliasgarzadeh A, Masnadi K, Tarzamani MK, Farhang S, Babaei H, Kiani J, Zaare M, Najafipoor F. N-acetylcysteine improves liver function in patients with non-alcoholic Fatty liver disease. Hepat Mon. 2010 Winter;10(1):12-6. Epub 2010 Mar 1. PMID: 22308119; PMCID: PMC3270338.;

[4] Arakawa M, Ito Y. N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology. Cerebellum. 2007;6(4):308-14. doi: 10.1080/14734220601142878. Epub 2007 Jan 19. PMID: 17853088; PMCID: PMC7102236.;

[5] Zhou J, Terluk MR, Orchard PJ, Cloyd JC, Kartha RV. N-Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy. Biomedicines. 2021 Dec 3;9(12):1826. doi: 10.3390/biomedicines9121826. PMID: 34944641; PMCID: PMC8698433.;

[6] Yedjou CG, Tchounwou CK, Haile S, Edwards F, Tchounwou PB. N-acetyl-cysteine protects against DNA damage associated with lead toxicity in HepG2 cells. Ethn Dis. 2010 Winter;20(1 Suppl 1):S1-101-3. PMID: 20521395; PMCID: PMC2902977.;

[7] Cazzola M. - Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis.;