irritated man, rubbing his eyes, stressed

Which Peptides Affect Sleep Quality And Why?

Do you find yourself unable to get a good night’s sleep? Many of us regularly experience disrupted sleep patterns, or insomnia, which can negatively impact our overall mental and physical health. Peptides are molecules that may be able to help us get better sleep, but what are they, and how do they work? This blog post will examine which peptides affect sleep quality and decipher why. We will also explore the science behind using peptides for better sleep, so you can decide if they suit you.

DSIP and Sleep

Delta sleep-inducing peptide (DSIP) is a naturally occurring peptide in the brain that plays a crucial role in regulating sleep. DSIP peptides in the hypothalamus region of the brain work by signaling to various receptors that help to promote sleep.

DSIP signaling directly affects sleep quality by increasing slow-wave sleep (SWS) and promoting deeper sleep. DSIP signaling also helps reduce the time it takes to fall asleep, leading to a more restful night’s sleep.

Overall, DSIP peptides are essential to healthy sleep and play a role in regulating sleep quality. By promoting more restorative sleep and reducing the occurrence of sleep disorders, DSIP can help to improve overall health and well-being.

man sleeping

Orexins and Sleep

The orexin system is another set of peptides impacting sleep quality. Orexins are produced by neurons in the hypothalamus, specifically in the lateral hypothalamus. The primary function of orexins is to regulate wakefulness by increasing activity in the brain’s arousal centers, particularly the brainstem and the basal forebrain. When orexin signaling is strong, it suppresses sleep-promoting neurons and stimulates the release of dopamine, a neurotransmitter associated with wakefulness and reward.

Disruptions in orexin signaling may contribute to sleep disorders such as narcolepsy and insomnia. Narcolepsy is expressed by excessive daytime sleepiness, sudden loss of muscle control (cataplexy), and disrupted REM sleep. Those with narcolepsy may have a deficiency of orexin-producing neurons, suggesting a lack of orexin signaling may contribute to this disorder.

Insomnia is a condition characterized by having difficulty falling asleep or staying asleep. While orexin signaling may not be directly responsible for insomnia, it can contribute to the development of the disorder.

woman with her head on the laptop, feeling sleepy

 In people with insomnia, the level of orexin in the cerebrospinal fluid is elevated, suggesting that excessive orexin signaling may cause hyperarousal, making falling or staying asleep difficult.

Overall, orexin signaling plays a crucial role in regulating wakefulness and arousal. Disruptions in orexin signaling can lead to sleep disorders, making it a critical target for potential sleep treatments.

Peptides That Improve Sleep Quality

First, let’s look at growth hormone-releasing hormone (GHRH). This peptide is naturally produced in the hypothalamus and regulates growth hormone secretion from the pituitary gland. However, studies have shown that GHRH can also improve deep sleep quality in healthy individuals and those with sleep disorders because GHRH increases slow-wave sleep, the deepest stage of sleep where the body repairs and rejuvenates itself. In addition, GHRH may result in improved memory consolidation and learning, both critical sleep functions.

Another peptide that can improve sleep quality is melatonin. Unlike GHRH, melatonin is a hormone produced in the pineal gland. It’s commonly known for regulating circadian rhythms but also directly promotes drowsiness at night. Melatonin is released when the body senses darkness, which helps to signal to the brain that it’s time to sleep. In addition, melatonin may help shorten the time it takes to fall asleep. 

Several peptides, including GHRH, melatonin, and thymosin alpha-1, can also improve sleep quality.

photo of brain

These peptides can promote more profound, restorative sleep and improve cognitive function the following day. If you’re struggling with sleep issues, it’s worth considering the potential benefits of these peptides and speaking with a medical professional before beginning any new supplement or medication.


Peptides play an essential role in regulating sleep quality. Understanding the specific peptides that affect sleep can help us improve the quality of life for those who struggle with them while developing new treatments for sleep disorders. DSIP may enhance sleep quality by increasing slow-wave sleep and reducing waking time. Conversely, orexins promote wakefulness and can cause insomnia if their levels are too high. By studying the effects of different peptides on sleep, researchers can identify potential targets for new treatments for sleep disorders. 

Consult with a medical professional if you are intrigued by the idea of peptide therapy to alleviate your sleeping difficulties. 

Peptide Shots - Frequently Asked Questions

What is included in our peptides injections?

There are many different peptide injections that we offer as part of a peptide therapy including Sermorelin, GHK-CU and PT-141.


Sermorelin is a synthetic form of GHRH (growth hormone-releasing hormone) which controls the hGH (human growth hormone) and it’s recommended to people who have low levels of hGH. 

How do peptides improve your sleep?

Serotonin is a neurotransmitter present in the brain that releases chemicals as messages to your brain and body that it is time to go to sleep. Some peptides can interact with serotonin. Serotonin regulation issues can definitely interfere with a person's ability to have a good night's sleep.

Sermorelin is recognized for their potency as peptides that enhance sleep.

How do peptides improve immune health?

The immune response can be either blocked or stimulated to produce tolerance using peptides and peptidomimetics as immunomodulating agents.

Read more: Peptide Shots FAQ